Los Alamos leverages the science and technology needed for its core mission to explore new solutions to challenges facing, many DOE program offices, including, Energy Efficiency and Renewable Energy (EERE), Office of Fossil Energy and Carbon Management (FECM), Office of Electricity (OE), US Department of Agriculture (USDA), and The Advanced Research Programs Agency-Energy (ARPA-E). The Science Program Office of Applied Energy (SPO-AE) coordinates the portfolio of R&D in this area, serving as the Lab's interface between applied-energy stakeholders and LANL's broad scientific and engineering base.

Los Alamos has a history of using its core capabilities to support DOE’s energy mission, a symbiotic relationship that has contributed innovative solutions to energy, while enriching the technical base Los Alamos needs to achieve its mission. Examples of this synergy include research in fuel-cells biosciences, the energy grid, and subsurface fossil and geothermal resources.